Frank Gibeau of Electronic Arts has shared that, if BioWare wants to do it, they’ll be allowed to work on more titles within the Mass Effect franchise. Assumably, if this happened, they’d also come to the Wii U. Here’s the full quote:
Does [Mass Effect 3's ending] mean you can never tell another story in the Mass Effect universe? No. If (BioWare’s) Casey decides on a story that he wants to tell, guess what? He’s going to be able to step forward at EA and we’re going to back him with capital for him to be able to go build that experience and tell a new story in the Mass Effect universe if that’s what he wants to do. If he wants to do something different, a new IP, he’ll have our backing as well. He’s a profoundly talented guy. He’s got our confidence. And the audience loves him. So that’s how it really works.
Original content is always good too, of course, but at the same time: Mass Effect is awesome. If they could work on a new story, they could use the lessons from their current work, minus the baggage that accumulated over the years. That could lead to something interesting.